Detalhe da pesquisa
1.
Functional polyamine metabolic enzymes and pathways encoded by the virosphere.
Proc Natl Acad Sci U S A
; 120(9): e2214165120, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802435
2.
Functional identification of bacterial spermine, thermospermine, norspermine, norspermidine, spermidine, and N1-aminopropylagmatine synthases.
J Biol Chem
; 300(5): 107281, 2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588807
3.
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii.
Proc Natl Acad Sci U S A
; 119(51): e2213116119, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36512492
4.
Neofunctionalization of S-adenosylmethionine decarboxylase into pyruvoyl-dependent L-ornithine and L-arginine decarboxylases is widespread in bacteria and archaea.
J Biol Chem
; 299(8): 105005, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399976
5.
Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis.
J Biol Chem
; 297(4): 101219, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560100
6.
Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin.
J Biol Chem
; 296: 100146, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33277357
7.
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.
PLoS Pathog
; 14(10): e1007404, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365568
8.
Polyamines in protozoan pathogens.
J Biol Chem
; 293(48): 18746-18756, 2018 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30333232
9.
Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei.
PLoS Pathog
; 12(11): e1006010, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27820863
10.
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Bioorg Med Chem
; 25(20): 5433-5440, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807574
11.
Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins.
J Biol Chem
; 290(32): 19987-98, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26082486
12.
GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.
Mol Microbiol
; 97(5): 1006-20, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26043892
13.
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.
J Chem Inf Model
; 56(3): 548-62, 2016 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26915022
14.
Chemical genetics of Plasmodium falciparum.
Nature
; 465(7296): 311-5, 2010 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20485428
15.
Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.
Antimicrob Agents Chemother
; 59(1): 686-9, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25331708
16.
Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications.
PLoS Pathog
; 9(5): e1003375, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23717205
17.
Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.
Eukaryot Cell
; 13(5): 614-24, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24610661
18.
Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.
Eukaryot Cell
; 13(4): 504-16, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24562907
19.
Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme.
J Biol Chem
; 288(7): 5232-40, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23288847
20.
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
J Biol Chem
; 288(21): 15256-67, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23525104